Endocrine Abstracts

SB, a 54-year-old male, was diagnosed with NF1 aged 11 on the basis of multiple café au lait spots and neurofibromas. In 1991 he presented with diarrhoea and weightloss and investigations revealed a duodenal mass and suspected hepatic metastases. Somatostatin levels were elevated, and histology confirmed a duodenal somatostatinma following Whipple’s procedure in 1991. The hepatic metastases were excised with good results. At follow up, SB remained symptom free treate...

The short Synacthen test (SST) is used to evaluate adrenal glucocorticoid secretion in response to synthetic ACTH (also known as tetracosactide or Synacthen). Traditionally, after a baseline cortisol and ACTH, two plasma cortisol samples have been taken after i.v. or i.m. administration of Synacthen 250 μg, one at 30 min and one at 60 min. However practice varies and some physicians only take one cortisol measurement at 30 min.Hypothesis: A protocol...

MM, a 51-year-old female was reviewed in the Endocrinology clinic for the assessment of hypercalcaemia, hyperprolactinaemia, and an adrenal mass. Bipolar depression had been diagnosed 24 years previously with continuous use of Lithium Carbonate since. An acute deterioration in mental state 3 years previously prompted Risperidone treatment which was ongoing. Hypercalcaemia (calcium=2.78 mmol/l, PTH=13.8 pmol/l, vitamin D=33 nmol/l) was recorded. Polyuria and nocturia was noted....